Fibrous Obliteration of Appendix Tip

Fibrous Obliteration of Appendix Tip

- Not secondary to appendicitis

Gross: white tip

Histology and Microscopy:

- Spindle cells and myxoid component

- Neuronal and Neuroendocrine cell proliferation

Immunohistochemistry: S100, chromogranin, Neuron specific enolase (NSE)

Differential diagnosis:

Neuroendocrine hyperplasia Carcinoid
Expansile growth of neuroendocrine cells Definite insular growth with extension to muscular wall
No gross nodule Gross nodule

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