Fibrous Obliteration of Appendix Tip

- Not secondary to appendicitis

Gross: white tip

Histology and Microscopy:

- Spindle cells and myxoid component

- Neuronal and Neuroendocrine cell proliferation

Immunohistochemistry: S100, chromogranin, Neuron specific enolase (NSE)

Differential diagnosis:

Neuroendocrine hyperplasia	Carcinoid
Expansile growth of neuroendocrine cells	Definite insular growth with extension to muscular wall
No gross nodule	Gross nodule